jamtJournal of Advanced Materials and TechnologiesJournal of Advanced Materials and Technologies2782-21922782-2206ФГБОУ ВО «ТГТУ»10.17277/jamt.2024.04.pp.276-285jamt-41Research ArticleБиологические материалы, наномедицина и новые технологии для клинического и медицинского примененияBiological materials; nanomedicine, and novel technologies for clinical and medical applicationsМеханизм взаимодействия компонентов нового лекарственного покрытия медицинских стентов на основе поливинилпирролидона с введенными углеродными нанотрубками и лекарственными препаратамиThe mechanism of interaction of a new drug coating components for medical stents based on polyvinylpyrrolidone with introduced carbon nanotubes and drugshttps://orcid.org/0000-0002-9486-2482ЗапороцковаИ. В.ZaporotskovaI. V.

Запороцкова Ирина Владимировна, доктор физико-математических наук, директор института

пр. Университетский, 100, Волгоград, 400062

Irina V. Zaporotskova, D. Sc. (Phys. and Math.),Director of the Institute

100, Universitetskiy Av., Volgograd, 400062

irinazaporotskova@gmail.comhttps://orcid.org/0000-0002-2695-1213ЧешеваМ. Ф.CheshevaM. F.

Чешева Мария Федоровна, ассистент

пр. Университетский, 100, Волгоград, 400062

Mariia F. Chesheva, Assistan

100, Universitetskiy Av., Volgograd, 400062

ЭлбакянЛ. С.ElbakyanL. S.

Элбакян Лусине Самвеловна, кандидат физико-математических наук, доцент

пр. Университетский, 100, Волгоград, 400062

Lusine S. Elbakyan, Cand. Sc. (Phys. and Math.),Associate Professor

100, Universitetskiy Av., Volgograd, 400062

Волгоградский государственный университетРоссияVolgograd State University (VolSU)Russian Federation20241302202694276285Copyright © Запороцкова И.В., Чешева М.Ф., Элбакян Л.С., 20262026Запороцкова И.В., Чешева М.Ф., Элбакян Л.С.Zaporotskova I.V., Chesheva M.F., Elbakyan L.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jamt.elpub.ru/jour/article/view/41

Практически все используемые в России стенты с лекарственными покрытиями произведены за рубежом и имеют высокую стоимость, что не может удовлетворять потребностям российских пациентов и их финансовым возможностям. В связи с этим актуальным является поиск и разработка новых типов покрытий медицинских стентов, а также налаживание их производства в РФ. Необходимо создание тонкопленочных лекарственных покрытий стентов с увеличенным временем испускания лекарственного препарата для лечения различных заболеваний. В качестве компонента, обеспечивающего пролонгированную и дозированную десорбцию лекарственного препарата с поверхности стента, лучше всего использовать полимерный носитель. В работе исследована возможность применения перспективного материала современности – углеродных нанотрубок – в качестве компонента лекарственного покрытия медицинского стента, который обеспечит не только улучшение физико-механических свойств покрытия, но и пролонгированное действие лекарственного препарата за счет увеличения времени его десорбции. Выполнены теоретические исследования механизмов взаимодействия компонентов лекарственных покрытий стентов на основе биополимера поливинилпирролидона, в состав которых входят лекарственные препараты (тегафур, дексаметазон) и углеродные нанотрубки. Исследования выполнены в рамках квантово-химического расчетного метода теории функционала плотности (DFT), который широко используется во всем мире для расчета наносистем.

Almost all stents with medicinal coatings used in Russia are manufactured abroad and have a high cost, which cannot meet the needs of Russian patients and their financial capabilities. The search and development of new types of medical stent coatings, as well as the establishment of their production in the Russian Federation is relevant. It is necessary to create thin-film drug coatings of stents with an extended time of drug emission for the treatment of various diseases. As a component providing prolonged and dosed desorption of the drug from the surface of the stent, it is best to use a carrier polymer. The paper investigates the possibility of using a promising modern material – carbon nanotubes – as a component of the medicinal coating of a medical stent, which will provide not only an improvement in the physical and mechanical properties of the coating, but also a prolonged effect of the drug by increasing its desorption time. Theoretical studies on the mechanisms of creating drug coatings for stents based on the polyvinylpyrrolidone copolymer, which include drugs (tegafur, dexamethasone) and carbon nanotubes, have been carried out. The quantum chemical calculation method – the density functional theory DFT, which is applied worldwide for calculating nanosystems, was used for research.

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The authors declare that there are no conflicts of interest present.