Surface modification of Gd2O3-graphene by different functionalities and captopril molecules
E. V. Suslova,
S. V. Yakovlev,
D. A. Shashurin,
D. A. Ipatova,
D. A. Skvortsov,
S. V. Maximov,
K. I. Maslakov,
Ya. B. Platonova,
S. V. Savilov,
G. A. Chelkov https://doi.org/10.17277/jamt-2026-11-01-069-080
Abstract
Nanoparticles of insoluble Gd3+ compounds are considered to be a promising direction of development of multimodal contrast agents for magnetic resonance imaging and computed tomography. The surface of such nanoparticles can be functionalized by molecules or chemical groups with high affinity to specific biopolymers. In the present work, we proposed a novel approach to obtaining such selective structures. At the first stage, Gd2O3 nanoparticles of 1–2 nm size stabilized on the surface of graphene nanoflakes (GNFs) were produced. Their further graphitization produced core-shell (Gd2O3/GNFs)@C particles. Treatment of these particles with nitric acid vapor resulted in the formation of surface carboxyl groups. Further reaction with SOCl2 produced (Gd2O3/GNFs)@C-COCl particles, which were used to obtain the esters containing the allyl fragment (Gd2O3/GNFs)@C-COOAll or molecules of specific inhibitor of angiotensin-converting enzyme captopril. All products were characterized by transmission electron microscopy, thermogravimetric analysis, IR and X-ray photoelectron spectroscopy. The results of these analyses confirmed that the functionalization of the particles by carboxyl, acyl chloride or allyl groups, as well as captopril molecules, did not change their morphology or the size of Gd2O3 cores. The cytotoxicity of (Gd2O3/GNFs)@C-COOH, (Gd2O3/GNFs)@C-COOAll and (Gd2O3/GNFs)@C-captopril particles was assessed.
Keywords
gadolinium,
graphene,
allyl,
captopril,
nanoparticles,
surface modification,
contrast agent,
cytotoxicity
Supporting agencies: This research was supported by Russian Science Foundation No. 22-15-00072-П. The authors acknowledge the support from the MSU Equipment Center “Nanochemistry and Nanomaterials”, operating within the framework of the Lomonosov Moscow State University Program of Development.
About the Authors
E. V. Suslova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Evgeniya V. Suslova - Cand. Sc. (Chem.), Senior Researcher, Chemistry Department, Lomonosov Moscow State University (MSU).
Bld. 3, 1, Leninskie Gory, Moscow, 119991
S. V. Yakovlev
Kurnakov Institute of General and Inorganic Chemistry RAS
Russian Federation
Russian Federation
Sergey V. Yakovlev - Engineer, Kurnakov Institute of General and Inorganic Chemistry RAS (IGIC RAS).
31, Leninskii Av., Moscow, 119991
D. A. Shashurin
Medicine Research-Educational Institute, Lomonosov Moscow State University; E.I. Chazov National Medical Research Center of Cardiology
Russian Federation
Russian Federation
Denis A. Shashurin - Cand. Sc. (Med.), Senior Researcher, Medicine Research-Educational Institute, MSU; E.I. Chazov National Medical Research Center of Cardiology.
Bld. 1, 27, Lomonosovskii Av., Moscow, 119991; 15A, Chazov St., Moscow, 121552
D. A. Ipatova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Daria A. Ipatova - PhD Student, Chemistry Department, MSU.
Bld. 3, 1, Leninskie Gory, Moscow, 119991
D. A. Skvortsov
Lomonosov Moscow State University
Russian Federation
Russian Federation
Dmitry A. Skvortsov - Cand. Sc. (Chem.), Associate Professor, Chemistry Department, MSU.
Bld. 3, 1, Leninskie Gory, Moscow, 119991
S. V. Maximov
Lomonosov Moscow State University
Russian Federation
Russian Federation
Sergey V. Maximov - Engineer, Chemistry Department, MSU.
Bld. 3, 1, Leninskie Gory, Moscow, 119991
K. I. Maslakov
Lomonosov Moscow State University
Russian Federation
Russian Federation
Konstantin I. Maslakov - Cand Sc. (Phys. and Math.), Senior Researcher, Chemistry Department, MSU.
Bld. 3, 1, Leninskie Gory, Moscow, 119991
Ya. B. Platonova
Lomonosov Moscow State University
Russian Federation
Russian Federation
Yana B. Platonova - Cand Sc. (Chem.), Researcher, Chemistry Department, MSU.
Bld. 3, 1, Leninskie Gory, Moscow, 119991
S. V. Savilov
Lomonosov Moscow State University; Kurnakov Institute of General and Inorganic Chemistry RAS
Russian Federation
Russian Federation
Serguei V. Savilov - D. Sc. (Chem.), Leading Researcher, Chemistry Department, MSU; IGIC RAS.
Bld. 3, 1, Leninskie Gory, Moscow, 119991; 31, Leninskii Av., Moscow, 119991
G. A. Chelkov
Joint Institute for Nuclear Research
Russian Federation
Russian Federation
Georgy A. Chelkov - Cand Sc. (Phys. and Math.), Leading Researcher, Chemistry Department, MSU; Joint Institute for Nuclear Research.
Moscow; 6, Joliot-Curie, Dubna, 141980
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For citations:
Suslova E.V., Yakovlev S.V., Shashurin D.A., Ipatova D.A., Skvortsov D.A., Maximov S.V., Maslakov K.I., Platonova Ya.B., Savilov S.V., Chelkov G.A. Surface modification of Gd2O3-graphene by different functionalities and captopril molecules. Journal of Advanced Materials and Technologies. 2026;11(1):69-80. https://doi.org/10.17277/jamt-2026-11-01-069-080
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